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Pilot study with technosphere/PTH(1-34)--a new approach for effective pulmonary delivery of parathyroid hormone (1-34)
Plain-language guide to PMID 12916003 (2003): pilot clinical trial study of Teriparatide and Parathyroid Hormone (PTH 1-84) in 10 volunteers.
Key Facts
- PMID
- 12916003
- Journal
- Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
- Year
- 2003
- Study type
- Clinical Trial
- Authors
- Pfützner A et al. (9 authors)
- DOI
- 10.1055/s-2003-41309
What This Study Did, in Plain Language
What Was Tested
Researchers studied Teriparatide and Parathyroid Hormone (PTH 1-84) in this clinical trial publication.
The treatments were administered in the morning after an overnight fast and blood samples for measurement of PTH(1 - 34), PTH(1 - 84), and calcium and calcitonin were taken over a period of 6 hours.
Who Took Part
According to the abstract, 10 volunteers were involved.
By PubMed's age tags, the people studied were adults, both men and women.
How the Study Was Run
In design terms this was a pilot study.
It is described as a pilot, a small early test of whether a larger Teriparatide study would be practical.
What Was Measured
The treatments were administered in the morning after an overnight fast and blood samples for measurement of PTH(1 - 34), PTH(1 - 84), and calcium and calcitonin were taken over a period of 6 hours.
Topics PubMed links to this paper include Biological Availability, Calcitonin, Calcium, Microspheres, Pilot Projects and Teriparatide.
What This Means in Plain Language
The paper is a pilot study of Teriparatide and Parathyroid Hormone (PTH 1-84) in 10 volunteers.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2003 (Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme), a journal based in Germany.
More context: the Teriparatide compound page and the Parathyroid Hormone (PTH 1-84) compound page, all human trials.
Our Notes on the Compounds
Teriparatide: A parathyroid hormone fragment, PTH(1-34), with human trials and approved-pen labeling; the research vial is not the approved pen.
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.