← Human Trials & Peer-Reviewed Studies
Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients.
Plain-language guide to PMID 12957441 (2003): double-blind randomized controlled trial of Antihypertensive Agents in 45 patients.
Key Facts
- PMID
- 12957441
- Journal
- Journal of the American College of Cardiology
- Year
- 2003
- Study type
- Randomized Controlled Trial
- Authors
- Koh KK et al. (10 authors)
- DOI
- 10.1016/s0735-1097(03)00846-5
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Antihypertensive Agents.
The researchers investigated the vascular effects of candesartan in hypertensive patients.
Why It Was Studied
The renin-angiotensin system may contribute to atherogenesis through the promotion of endothelial dysfunction.
The plausible mechanisms are that angiotensin II promotes superoxide anion generation, endothelial dysfunction, inflammation, and impaired fibrinolysis.
Who Took Part
The study group was 45 patients.
The age groups tagged for this paper are middle-aged adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.
The patients were allocated by chance, so the Antihypertensive Agents group and the comparison group should start out alike.
Neither the patients nor the staff measuring them knew who was on Antihypertensive Agents, so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Antihypertensive Agents could be set against what happens without it.
In the crossover set-up each of the patients took both Antihypertensive Agents and the comparison in turn, acting as their own control.
This was a randomized, double-blind, placebo-controlled, crossover study in design.
What Was Measured
The subject headings attached to it are Angiotensin Receptor Antagonists, Angiotensins, Antihypertensive Agents, Benzimidazoles, Biphenyl Compounds, Chemokine CCL2 and Fibrinolysis.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Antihypertensive Agents in 45 patients.
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2003 (Journal of the American College of Cardiology), a journal based in United States.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.