Danazol induces resistance to both insulin and glucagon in young women

What Was Tested

Researchers studied Glucagon in the context of insulin resistance, prediabetes & type 2 diabetes in this randomized controlled trial publication.

Eleven women underwent intravenous glucose tolerance tests with measurement of plasma glucose, insulin, C-peptide and glucagon concentrations and modelling analysis of intravenous glucose tolerance test concentration profiles.

Six women underwent glucagon sensitivity tests.

Who Took Part

According to the abstract, 17 women were involved.

The age groups tagged for this paper are adults, women only.

How the Study Was Run

The researchers set it up as a randomized study.

Because people in this Glucagon study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Serum concentrations of lipids and lipoproteins were measured in all cases. 3.

What Was Measured

Eleven women underwent intravenous glucose tolerance tests with measurement of plasma glucose, insulin, C-peptide and glucagon concentrations and modelling analysis of intravenous glucose tolerance test concentration profiles.

Six women underwent glucagon sensitivity tests.

Topics PubMed links to this paper include Blood Glucose, C-Peptide, Cholesterol, Danazol, Endometriosis, Glucagon and Insulin.

What This Means in Plain Language

The paper is a randomized study of Glucagon in 17 women in people with insulin resistance, prediabetes & type 2 diabetes.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1992 (Clinical science (London, England : 1979)), a journal based in England.

More context: the Glucagon compound page, Insulin resistance, prediabetes & type 2 diabetes research.