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Plasminogen activation in vivo upon intravenous infusion of DDAVP. Quantitative assessment of plasmin-alpha 2-antiplasmin complex with a novel monoclonal antibody based radioimmunoassay
Plain-language guide to PMID 1377412 (1992): placebo-controlled randomized controlled trial study of Vasopressin and Desmopressin.
Key Facts
- PMID
- 1377412
- Journal
- Thrombosis and haemostasis
- Year
- 1992
- Study type
- Randomized Controlled Trial
- Authors
- Levi M et al. (5 authors)
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vasopressin and Desmopressin, published as a randomized controlled trial.
A novel sensitive radioimmunoassay (RIA) for the measurement of the complex between plasmin and its main inhibitor alpha 2-antiplasmin (PAP complex) was developed using monoclonal antibodies preferentially reacting with complexed and inactivated alpha 2-antiplasmin and monoclonal antibodies against plasmin.
The assay was validated in healthy volunteers and in patients with an activated fibrinolytic system.
Who Took Part
PubMed indexes the participants as adults.
How the Study Was Run
The design is described as randomized, placebo-controlled and crossover.
The participants were allocated by chance, so the Vasopressin group and the comparison group should start out alike.
The comparison arm used a placebo, so changes seen with Vasopressin could be set against what happens without it.
In the crossover set-up each of the participants took both Vasopressin and the comparison in turn, acting as their own control.
What Was Measured
A novel sensitive radioimmunoassay (RIA) for the measurement of the complex between plasmin and its main inhibitor alpha 2-antiplasmin (PAP complex) was developed using monoclonal antibodies preferentially reacting with complexed and inactivated alpha 2-antiplasmin and monoclonal antibodies against plasmin.
Topics PubMed links to this paper include Antibodies, Monoclonal, Deamino Arginine Vasopressin, Disseminated Intravascular Coagulation, Fibrinolysin, Fibrinolysis, In Vitro Techniques and Plasminogen.
What This Means in Plain Language
The paper is a randomized, placebo-controlled and crossover study of Vasopressin and Desmopressin.
The publication is from 1992 (Thrombosis and haemostasis), a journal based in Germany.
More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.
Our Notes on the Compounds
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Desmopressin: A synthetic vasopressin analog (DDAVP) used for bedwetting, diabetes insipidus and some bleeding disorders.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.