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The comparison of two gonadotropin-releasing hormone agonists in an in vitro fertilization program.

Plain-language guide to PMID 1426388 (1992): randomized controlled trial of Chorionic Gonadotropin and Buserelin.

Key Facts

PMID
1426388
Journal
Fertility and sterility
Year
1992
Study type
Randomized Controlled Trial
Authors
Balasch J et al. (6 authors)
DOI
10.1016/s0015-0282(16)55448-x

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Chorionic Gonadotropin and Buserelin, published as a randomized controlled trial.

To compare two gonadotropin-releasing hormone agonists (GnRH-a), buserelin acetate and leuprolide acetate [LA], used in combination with gonadotropins in ovarian stimulation for in vitro fertilization (IVF).

Who Took Part

The age groups tagged for this paper are adults, women only.

Thirty-five pairs of IVF patients who were matched on age, indication, and number of attempts.

These women were randomized to receive either buserelin acetate plus gonadotropins (group B) or LA plus gonadotropins (group L).

How the Study Was Run

The researchers set it up as a randomized study.

Because people in this Chorionic Gonadotropin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Assisted Reproduction Unit of the Hospital Clínic i Provincial in Barcelona.

What Was Measured

PubMed files the paper under topics including Buserelin, Chorionic Gonadotropin, Corpus Luteum, Cryopreservation, Embryo, Mammalian, Estradiol and Fertilization in Vitro.

What This Means in Plain Language

The paper is a randomized study of Chorionic Gonadotropin and Buserelin.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1992 (Fertility and sterility), a journal based in United States.

More context: the related hCG (human chorionic gonadotropin) library page, all human trials.

Related Library Page

hCG (human chorionic gonadotropin): An LH analog that drives Leydig-cell testosterone production.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.