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Lack of effect of a single i.v. dose of oxytocin on sperm output in severely oligozoospermic men
Plain-language guide to PMID 14507828 (2003): single-blind randomized controlled trial study of Oxytocin.
Key Facts
- PMID
- 14507828
- Journal
- Human reproduction (Oxford, England)
- Year
- 2003
- Study type
- Randomized Controlled Trial
- Authors
- Byrne MM et al. (5 authors)
- DOI
- 10.1093/humrep/deg416
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Oxytocin.
The aim of this randomized single-blind cross-over study was to establish the effects of oxytocin on sperm output in severely oligozoospermic men.
Why It Was Studied
ICSI into the oocyte is the only treatment currently available for most male patients with severe oligozoospermia who wish to father children.
In order to perform ICSI, motile sperm need to be recovered from the ejaculate and, if no sperm or not enough motile sperm are recovered on the day of ICSI, testicular sperm extraction (TESE) must be performed.
Who Took Part
By PubMed's age tags, the people studied were adults, men only.
How the Study Was Run
The design is described as randomized, single-blind and crossover.
Because people in this Oxytocin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Only one side, usually the participants, was kept unaware of whether Oxytocin was given.
In the crossover set-up each of the participants took both Oxytocin and the comparison in turn, acting as their own control.
Ejaculate analysis was performed according to the WHO 1999 guidelines.
What Was Measured
In order to perform ICSI, motile sperm need to be recovered from the ejaculate and, if no sperm or not enough motile sperm are recovered on the day of ICSI, testicular sperm extraction (TESE) must be performed.
PubMed files the paper under topics including Ejaculation, Estradiol, Follicle Stimulating Hormone, Oligospermia, Oxytocin, Semen and Sperm Count.
What This Means in Plain Language
The paper is a randomized, single-blind and crossover study of Oxytocin.
The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2003 (Human reproduction (Oxford, England)), a journal based in England.
More context: the Oxytocin compound page, all human trials.
Our Notes on the Compound
Oxytocin: A peptide hormone with established obstetric medical uses and a less settled role in research on behavior, sexual function and appetite.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.