[Optimal time for the administration of rhGH in severely burned patients--analysis of the dynamic changes of IGF axis and blood sugar].

What Was Tested

Researchers studied Human Growth Hormone in this randomized controlled trial publication.

To investigate the effects of recombinant human growth hormone (rhGH) on the changes in serum insulin-like growth factor-I (IGF-I), IGF binding protein 3 (IGFBP-3) and blood sugar in severely burned patients, so as to validate the optimal time of rhGH administration.

Who Took Part

The abstract describes 3 patients taking part.

PubMed indexes the participants as adults and middle-aged adults, both men and women.

Forty severely burned patients were enrolled in the study and were randomly divided into control (C), treatment 1 (rhGH given from 7 - 9 PBD, T1) and treatment 2 (rhGH from 10 - 14 PBD, T2) groups.

The dynamic changes in serum IGF-I, IGFBP-3 and blood sugar on the 1, 3, 5, 7, 10, 14 and 21 PBDs in all 3 groups of burn patients were determined, analyzed and compared with one another.

How the Study Was Run

The design is described as randomized.

Because people in this Human Growth Hormone study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

What Was Measured

The subject headings attached to it are Blood Glucose, Burns, Human Growth Hormone, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor I and Recombinant Proteins.

What This Means in Plain Language

The paper is a randomized study of Human Growth Hormone in 3 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2003 (Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns), a journal based in China.

More context: the related Exogenous HGH, sermorelin & older GHRPs (why they're passed over) library page, all human trials.