Effect of gonadotropin-releasing hormone agonist and medroxyprogesterone acetate on calcium metabolism: a prospective, randomized, double-blind, placebo-controlled, crossover trial.

What Was Tested

This randomized controlled trial looks at Leuprolide and Gonadotropin-Releasing Hormone.

Who Took Part

By PubMed's age tags, the people studied were adults, women only.

Twenty women were randomized into protocol A or B, received either MPA or placebo along with GnRH-a, and were then crossed over at 12 weeks to placebo or MPA, for the final 12-week interval of GnRH-a therapy.

Collection of serum and urine samples and measurement of bone density.

How the Study Was Run

The design is described as randomized, double-blind, placebo-controlled and crossover.

Because people in this Leuprolide study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the participants nor the staff measuring them knew who was on Leuprolide, so expectations could not easily colour the readings.

A placebo (an inactive look-alike) gave the Leuprolide group a baseline to be compared against.

In the crossover set-up each of the participants took both Leuprolide and the comparison in turn, acting as their own control.

Prospective, randomized, double-blind, placebo-controlled, crossover trial.

Clinical research center, university hospital.

Sex hormone, calcitropic hormone, and bone density studies were performed at baseline and at 12 and 24 weeks.

What Was Measured

PubMed files the paper under topics including Bone Density, Calcium, Endometriosis, Gonadotropin-Releasing Hormone, Homeostasis, Leiomyomatosis and Leuprolide.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Leuprolide and Gonadotropin-Releasing Hormone.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2003 (Fertility and sterility), a journal based in United States.

More context: the related Leuprolide library page, all human trials.