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Highly purified human-derived follicle-stimulating hormone (Bravelle) has equivalent efficacy to follitropin-beta (Follistim) in infertile women undergoing in vitro fertilization.
Plain-language guide to PMID 14609434 (2003): multicenter randomized controlled trial of Chorionic Gonadotropin and Follicle Stimulating Hormone.
Key Facts
- PMID
- 14609434
- Journal
- Reproductive biology and endocrinology : RB&E
- Year
- 2003
- Study type
- Randomized Controlled Trial
- Authors
- Dickey RP et al. (9 authors)
- DOI
- 10.1186/1477-7827-1-63
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Chorionic Gonadotropin and Follicle Stimulating Hormone, published as a randomized controlled trial.
Who Took Part
By PubMed's age tags, the people studied were teenagers and adults, women only.
Infertile premenopausal women underwent pituitary down-regulation using leuprolide acetate followed by a maximum of 12 days of subcutaneous Bravelle (n = 120) or Follistim (n = 118), followed by administration of human chorionic gonadotropin, oocyte retrieval and embryo transfer.
How the Study Was Run
The researchers set it up as a randomized, multicenter and parallel-group study.
The participants were allocated by chance, so the Chorionic Gonadotropin group and the comparison group should start out alike.
Running at several centres spread the Chorionic Gonadotropin study over different clinics and patient groups.
Groups ran in parallel: each of the participants stayed in one arm throughout.
This report describes the pooled data from two, nearly identical, randomized, controlled, parallel-group, multicenter studies conducted in a total of 19 academic and private IVF-ET centers in the United States.
What Was Measured
The subject headings attached to it are Chorionic Gonadotropin, Embryo Transfer, Fertilization in Vitro, Follicle Stimulating Hormone, Follicle Stimulating Hormone, Human, Infertility, Female and Leuprolide.
What This Means in Plain Language
The paper is a randomized, multicenter and parallel-group study of Chorionic Gonadotropin and Follicle Stimulating Hormone.
Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2003 (Reproductive biology and endocrinology : RB&E), a journal based in England.
More context: the related hCG (human chorionic gonadotropin) library page, all human trials.
Related Library Page
hCG (human chorionic gonadotropin): An LH analog that drives Leydig-cell testosterone production.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.