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Final height data, body composition and glucose metabolism in growth hormone-treated short children born small for gestational age.
Plain-language guide to PMID 14671407 (2003): double-blind randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 165 children.
Key Facts
- PMID
- 14671407
- Journal
- Hormone research
- Year
- 2003
- Study type
- Randomized Controlled Trial
- Authors
- Hokken-Koelega AC et al. (4 authors)
- DOI
- 10.1159/000074511
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
For this reason concern has been expressed regarding the possible detrimental effects of GH therapy in children born small for gestational age (SGA).
The inclusion criteria were: (1) birth length standard deviation score (SDS) below -2; (2) age 3-8 years; (3) height SDS below -2.
Who Took Part
The abstract describes 165 children taking part.
The age groups tagged for this paper are young children and children.
How the Study Was Run
In design terms this was a randomized, double-blind and multicenter study.
Random assignment meant chance, not the researchers, decided who got Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and who got the comparison, which limits bias.
As a double-blind Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study, the assignments were hidden from both participants and investigators until the end.
More than one site took part, so the children came from several places.
What Was Measured
The inclusion criteria were: (1) birth length standard deviation score (SDS) below -2; (2) age 3-8 years; (3) height SDS below -2.
Subjects underwent standard oral glucose tolerance tests and measurement of body mass index, systolic and diastolic blood pressure and serum lipids at baseline and after 1 and 6 years of GH therapy and again 6 months after discontinuation of GH.
The subject headings attached to it are Blood Glucose, Body Composition, Body Height, Growth Disorders, Growth Hormone and Infant, Small for Gestational Age.
What This Means in Plain Language
The paper is a randomized, double-blind and multicenter study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 165 children.
The publication is from 2003 (Hormone research), a journal based in Switzerland.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.