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Copper enzyme activities in cystic fibrosis before and after copper supplementation plus or minus zinc
Plain-language guide to PMID 14681839 (2004): placebo-controlled randomized controlled trial study of Copper (Supplement).
Key Facts
- PMID
- 14681839
- Journal
- Metabolism: clinical and experimental
- Year
- 2004
- Study type
- Randomized Controlled Trial
- Authors
- Best K et al. (4 authors)
- DOI
- 10.1016/j.metabol.2003.07.017
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Copper (Supplement).
The present study attempted to confirm this proposition in 3 ways: repeat the measures for 1 of the 2 copper enzymes (superoxide dismutase) in a new group of CF patients (males and females, N = 38), add another copper enzyme measure (plasma diamine oxidase) that has high sensitivity to copper status, and test if copper enzyme activities in CF patients rise by copper supplementation.
The last test was performed plus or minus zinc supplementation since poor zinc status may contribute to poor copper status.
Who Took Part
The age groups tagged for this paper are children, teenagers, adults and middle-aged adults, both men and women.
How the Study Was Run
In design terms this was a randomized and placebo-controlled study.
The participants were allocated by chance, so the Copper (Supplement) group and the comparison group should start out alike.
Some participants received a placebo instead of Copper (Supplement), giving a reference point.
What Was Measured
The present study attempted to confirm this proposition in 3 ways: repeat the measures for 1 of the 2 copper enzymes (superoxide dismutase) in a new group of CF patients (males and females, N = 38), add another copper enzyme measure (plasma diamine oxidase) that has high sensitivity to copper status, and test if copper enzyme activities in CF patients rise by copper supplementation.
The last test was performed plus or minus zinc supplementation since poor zinc status may contribute to poor copper status.
The subject headings attached to it are Amine Oxidase (Copper-Containing), Ceruloplasmin, Copper, Cystic Fibrosis, Dietary Supplements, Erythrocytes and Superoxide Dismutase.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Copper (Supplement).
The publication is from 2004 (Metabolism: clinical and experimental), a journal based in United States.
More context: the Copper (Supplement) compound page, all human trials.
Our Notes on the Compound
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.