Lipid, glucose and homocysteine metabolism in women treated with a GnRH agonist with or without raloxifene.

What Was Tested

This randomized controlled trial looks at Leuprolide and Raloxifene Hydrochloride.

Although GnRH analogues are widely used to treat a variety of sex hormone-related diseases, little is known about their effect on metabolism.

Therefore, the researchers have evaluated the effect of a GnRH analogue, administered with or without raloxifene, on serum levels of lipoproteins, glucose, insulin and homocysteine (Hcy).

Who Took Part

PubMed indexes the participants as adults and middle-aged adults, women only.

At entry and at cycle 6, subjects underwent anthropometric measurements, including body mass index and waist-to-hip ratio measurements, and blood chemistry assays for serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, insulin, Hcy, vitamin B(12) and folate concentrations.

Insulin resistance was evaluated with the homeostasis model assessment (HOMA) score.

How the Study Was Run

In design terms this was a randomized and placebo-controlled study.

The participants were allocated by chance, so the Leuprolide group and the comparison group should start out alike.

Some participants received a placebo instead of Leuprolide, giving a reference point.

What Was Measured

Therefore, the researchers have evaluated the effect of a GnRH analogue, administered with or without raloxifene, on serum levels of lipoproteins, glucose, insulin and homocysteine (Hcy).

Topics PubMed links to this paper include Blood Glucose, Body Constitution, Body Mass Index, Cholesterol, Cholesterol, HDL, Cholesterol, LDL and Folic Acid.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Leuprolide and Raloxifene Hydrochloride.

The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2004 (Human reproduction (Oxford, England)), a journal based in England.

More context: the related Leuprolide library page, all human trials.