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Serum dehydroepiandrosterone sulfate levels and pubarche in short children born small for gestational age before and during growth hormone treatment.
Plain-language guide to PMID 14764786 (2004): double-blind randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 181 children.
Key Facts
- PMID
- 14764786
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 2004
- Study type
- Randomized Controlled Trial
- Authors
- Boonstra VH et al. (4 authors)
- DOI
- 10.1210/jc.2003-031160
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
As a result, children born small for gestational age (SGA) might have several hormonal disturbances.
In later life, one of the questions that might arise is: Do short children born SGA have higher serum dehydroepiandrosterone sulfate (DHEAS) levels than their peers?
Who Took Part
The study group was 181 children.
The age groups tagged for this paper are young children and children, both men and women.
How the Study Was Run
The design is described as randomized and double-blind.
Random assignment meant chance, not the researchers, decided who got Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and who got the comparison, which limits bias.
Blinding on both sides kept the children and researchers unaware of who received Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
What Was Measured
In later life, one of the questions that might arise is: Do short children born SGA have higher serum dehydroepiandrosterone sulfate (DHEAS) levels than their peers?
Therefore, the researchers compared serum DHEAS levels of 181 short prepubertal children aged 3-9 yr born SGA [birth length (SD score) below -2 for gestational age] with a control group of 170 prepubertal age-matched, normal-statured children born appropriate for gestational age (birth length between -2 and +2 SD score).
The subject headings attached to it are Body Height, Dehydroepiandrosterone Sulfate, Growth Hormone, Incidence, Infant, Small for Gestational Age, Puberty and Puberty, Precocious.
What This Means in Plain Language
The paper is a randomized and double-blind study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 181 children.
The publication is from 2004 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.