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Equivalence of the 3-month and 28-day formulations of triptorelin with regard to achievement and maintenance of medical castration in women with endometriosis
Plain-language guide to PMID 14967363 (2004): multicenter randomized controlled trial study of Triptorelin in 74 patients, endometriosis.
Key Facts
- PMID
- 14967363
- Journal
- Fertility and sterility
- Year
- 2004
- Study type
- Randomized Controlled Trial
- Authors
- Donnez J et al. (7 authors)
- DOI
- 10.1016/j.fertnstert.2003.07.013
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Triptorelin in the context of endometriosis, published as a randomized controlled trial.
Who Took Part
The study group was 74 patients.
PubMed indexes the participants as adults, women only.
A phase II, prospective, randomized, multicenter, open study was conducted in two parallel groups of women with endometriosis.
Seventy-two women with endometriosis. were treated with a single intramuscular injection of 3-month triptorelin SR, and 74 patients were treated with one intramuscular injection of 28-day triptorelin SR every 28 days for 3 months.
How the Study Was Run
The design is described as randomized, multicenter and parallel-group.
Random assignment meant chance, not the researchers, decided who got Triptorelin and who got the comparison, which limits bias.
Running at several centres spread the Triptorelin study over different clinics and patient groups.
Groups ran in parallel: each of the patients stayed in one arm throughout.
A time span of 3 months appears in the methods.
As part of two parallel treatment groups, 72 women were given a single intramuscular injection of 3-month triptorelin SR, and 74 women were given one intramuscular injection of 28-day triptorelin SR every 28 days for 3 months.
What Was Measured
The subject headings attached to it are Endometriosis, Estradiol, Follicle Stimulating Hormone, Luteinizing Hormone, Luteolytic Agents, Recurrence and Triptorelin Pamoate.
What This Means in Plain Language
The paper is a randomized, multicenter and parallel-group study of Triptorelin in 74 patients in people with endometriosis over 3 months.
The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2004 (Fertility and sterility), a journal based in United States.
More context: the Triptorelin compound page, Endometriosis research.
Our Notes on the Compound
Triptorelin: A 10-amino-acid GnRH analog (Trelstar, Decapeptyl, Triptodur) used in prostate cancer, early puberty and fertility protocols.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.