Evaluation of myocardial protection by combination of lidoflazine pretreatment and St. Thomas' Hospital cardioplegia in aorto-coronary bypass grafting.

What Was Tested

This randomized controlled trial looks at Lidoflazine.

The purpose of this study was to determine whether the combination of lidoflazine pretreatment and St.

Why It Was Studied

Thomas' Hospital cardioplegia can provide, in clinical practice, better myocardial protection in aorto-coronary bypass grafting than St.

As indices for myocardial protection, recovery of cardiac function, enzyme release, and clinical outcome were registered.

Who Took Part

The age groups tagged for this paper are middle-aged adults and older adults, both men and women.

These patients were randomized into two groups in a double blind fashion.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

The participants were allocated by chance, so the Lidoflazine group and the comparison group should start out alike.

Neither the participants nor the staff measuring them knew who was on Lidoflazine, so expectations could not easily colour the readings.

A placebo (an inactive look-alike) gave the Lidoflazine group a baseline to be compared against.

What Was Measured

As indices for myocardial protection, recovery of cardiac function, enzyme release, and clinical outcome were registered.

The subject headings attached to it are Bicarbonates, Blood Pressure, Calcium Chloride, Cardiac Output, Cardioplegic Solutions, Coronary Artery Bypass and Creatine Kinase.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Lidoflazine.

The publication is from 1992 (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery), a journal based in Germany.

More context: all human trials.