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Short-term testosterone supplementation relieves growth hormone autonegative feedback in men.
Plain-language guide to PMID 15001624 (2004): double-blind randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 13 men.
Key Facts
- PMID
- 15001624
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 2004
- Study type
- Randomized Controlled Trial
- Authors
- Veldhuis JD et al. (5 authors)
- DOI
- 10.1210/jc.2003-031017
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a randomized controlled trial.
The present study tests the postulate that testosterone (Te) stimulates GH secretion, in part, by attenuating autonegative feedback.
Blood was withdrawn every 10 min, GH concentrations were quantitated by chemiluminometry, secretion was determined by deconvolution analysis, and outcomes were compared by ANOVA.
Who Took Part
The abstract describes 13 men taking part.
The age groups tagged for this paper are middle-aged adults and older adults, men only.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and parallel-group.
The men were allocated by chance, so the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group and the comparison group should start out alike.
Blinding on both sides kept the men and researchers unaware of who received Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
The comparison arm used a placebo, so changes seen with Exogenous HGH, sermorelin & older GHRPs (why they're passed over) could be set against what happens without it.
The Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group and the comparison group ran side by side rather than switching.
What Was Measured
The present study tests the postulate that testosterone (Te) stimulates GH secretion, in part, by attenuating autonegative feedback.
Blood was withdrawn every 10 min, GH concentrations were quantitated by chemiluminometry, secretion was determined by deconvolution analysis, and outcomes were compared by ANOVA.
PubMed files the paper under topics including Androgens, Fasting, Feedback, Physiological, Growth Hormone, Human Growth Hormone, Pulsatile Flow and Testosterone.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 13 men.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2004 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.