Effects of the angiotensin II receptor blockers telmisartan versus valsartan on the circadian variation of blood pressure: impact on the early morning period.

Plain-language guide to PMID 15062889 (2004): double-blind randomized controlled trial of Antihypertensive Agents in 490 patients, low blood pressure and orthostatic hypotension.

Key Facts

PMID: 15062889
Journal: American journal of hypertension
Year: 2004
Study type: Randomized Controlled Trial
Authors: White WB et al. (3 authors)
DOI: 10.1016/j.amjhyper.2004.02.016

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Antihypertensive Agents in the context of low blood pressure and orthostatic hypotension.

Who Took Part

The abstract describes 490 patients taking part.

PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.

The patients were allocated by chance, so the Antihypertensive Agents group and the comparison group should start out alike.

Blinding on both sides kept the patients and researchers unaware of who received Antihypertensive Agents.

Some patients received a placebo instead of Antihypertensive Agents, giving a reference point.

Each person switched between Antihypertensive Agents and the comparison at some point, usually with a gap in between.

Ambulatory BP recordings were performed at baseline after a placebo period and again after 6 and 8 weeks of double-blind therapy in a randomized cross-over design.

What Was Measured

PubMed files the paper under topics including Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Benzimidazoles, Benzoates, Blood Pressure and Blood Pressure Monitoring, Ambulatory.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Antihypertensive Agents in 490 patients in people with low blood pressure and orthostatic hypotension.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2004 (American journal of hypertension), a journal based in United States.

More context: Low blood pressure and orthostatic hypotension research.

Low blood pressure and orthostatic hypotension research

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.