Nesiritide in congestive heart failure associated with acute coronary syndromes: a pilot study of safety and efficacy

What Was Tested

The paper reports a study of BNP (Nesiritide), published as a randomized controlled trial.

Who Took Part

The study group was 5 patients.

The age groups tagged for this paper are middle-aged adults, both men and women.

Sixty-one patients were included; 34 received nesiritide and 27 received NTG.

Pulmonary capillary wedge pressure was measured in right heart-catheterized patients (11 nesiritide, 9 NTG).

How the Study Was Run

The design is described as randomized, double-blind and pilot.

Because people in this BNP (Nesiritide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the patients nor the staff measuring them knew who was on BNP (Nesiritide), so expectations could not easily colour the readings.

It is described as a pilot, a small early test of whether a larger BNP (Nesiritide) study would be practical.

What Was Measured

Topics PubMed links to this paper include Acute Disease, Cardiac Catheterization, Coronary Disease, Heart Failure, Natriuretic Peptide, Brain, Nitroglycerin and Pilot Projects.

What This Means in Plain Language

The paper is a randomized, double-blind and pilot study of BNP (Nesiritide) in 5 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 1 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2004 (Journal of cardiac failure), a journal based in United States.

More context: the BNP (Nesiritide) compound page, all human trials.