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Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers
Plain-language guide to PMID 15203290 (2004): double-blind randomized controlled trial study of ACTH (Corticotropin) and Vasopressin.
Key Facts
- PMID
- 15203290
- Journal
- Journal of psychiatric research
- Year
- 2004
- Study type
- Randomized Controlled Trial
- Authors
- Zimmermann U et al. (7 authors)
- DOI
- 10.1016/j.jpsychires.2003.11.009
What This Study Did, in Plain Language
What Was Tested
Researchers studied ACTH (Corticotropin) and Vasopressin in this randomized controlled trial publication.
Familial risk and environmental stress promote the development of alcohol dependence.
The researchers investigated whether a positive family history of alcoholism affects the neuroendocrine response to a standardized laboratory stress test in healthy subjects without alcohol use disorders.
Who Took Part
PubMed indexes the participants as teenagers and adults, men only.
Twenty-four high-risk subjects with a paternal history of alcoholism (PHA) and 16 family history negative (FHN) controls were evaluated.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
The participants were allocated by chance, so the ACTH (Corticotropin) group and the comparison group should start out alike.
As a double-blind ACTH (Corticotropin) study, the assignments were hidden from both participants and investigators until the end.
Some participants received a placebo instead of ACTH (Corticotropin), giving a reference point.
Adrenocorticotropin (ACTH) was measured in 10 plasma samples covering up to 75 min after the stress test.
What Was Measured
The researchers investigated whether a positive family history of alcoholism affects the neuroendocrine response to a standardized laboratory stress test in healthy subjects without alcohol use disorders.
The subject headings attached to it are Adrenocorticotropic Hormone, Alcoholism, Arginine Vasopressin, Central Nervous System Depressants, Ethanol, Genetic Predisposition to Disease and Hypothalamo-Hypophyseal System.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of ACTH (Corticotropin) and Vasopressin.
The publication is from 2004 (Journal of psychiatric research), a journal based in England.
More context: the ACTH (Corticotropin) compound page and the Vasopressin compound page, all human trials.
Our Notes on the Compounds
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.