Renal response to lithogenic and anti-lithogenic supplement challenges in a stone-free population group.

What Was Tested

Researchers studied Cysteine and Diet in this controlled clinical trial publication.

In South Africa, urolithiasis is extremely rare in the black population, but is common in the white population.

The objective of this study was to investigate the individual effects of 5 different dietary and supplemental challenges (high dietary calcium, calcium supplement, vitamin B6 supplement, L-glutamine supplement, and L-cysteine supplement) on the urinary risk factors for calcium oxalate urolithiasis in subjects from both race groups.

Who Took Part

The abstract describes 10 subjects taking part.

PubMed indexes the participants as teenagers and adults, men only.

Subjects were recruited from the student cohort of the University of Cape Town (10 male subjects from each race group).

Selection criteria were no history of renal or metabolic diseases, and no chronic or acute medication.

How the Study Was Run

Subjects served as their own controls.

These were analyzed for biochemical and physicochemical risk factors.

Additionally, 24-hour dietary recall questionnaires were recorded at baseline and after the 5-day test period, and were analyzed using a food analysis program.

Statistical analysis of variance was performed on all of the data.

What Was Measured

The subject headings attached to it are Black People, Calcium, Calcium Oxalate, Calcium Phosphates, Calcium, Dietary, Citric Acid and Cohort Studies.

What This Means in Plain Language

This is a controlled clinical trial of Cysteine and Diet in 10 subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2004 (Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation), a journal based in United States.

More context: all human trials.