Aldosterone synthase gene variation and adrenocortical response to sodium status, angiotensin II and ACTH in normal male subjects

What Was Tested

This randomized controlled trial paper looks at ACTH (Corticotropin) and Angiotensin II.

Aldosterone synthase, a key enzyme in the terminal steps of aldosterone synthesis, is encoded by the CYP11B2 gene.

A second polymorphism (a conversion in intron 2 to resemble that of the neighbouring 11beta-hydroxylase (CYP11B1) gene) is found in close linkage dysequilibrium with the variant at -344 C/T.

Who Took Part

PubMed indexes the participants as adults, men only.

The researchers performed a focused physiological study in normal volunteers stratified by CYP11B2 genotype.

How the Study Was Run

In design terms this was a randomized, double-blind and crossover study.

The participants were allocated by chance, so the ACTH (Corticotropin) group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received ACTH (Corticotropin).

Each person switched between ACTH (Corticotropin) and the comparison at some point, usually with a gap in between.

What Was Measured

The subject headings attached to it are Adrenal Cortex, Adrenocorticotropic Hormone, Aldosterone, Angiotensin II, Corticosterone, Cortodoxone and Cytochrome P-450 CYP11B2.

What This Means in Plain Language

The paper is a randomized, double-blind and crossover study of ACTH (Corticotropin) and Angiotensin II.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2004 (Clinical endocrinology), a journal based in England.

More context: the ACTH (Corticotropin) compound page and the Angiotensin II compound page, all human trials.