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Copper, selenium, zinc, and thiamine balances during continuous venovenous hemodiafiltration in critically ill patients.
Plain-language guide to PMID 15277163 (2004): crossover randomized controlled trial.
Key Facts
- PMID
- 15277163
- Journal
- The American journal of clinical nutrition
- Year
- 2004
- Study type
- Randomized Controlled Trial
- Authors
- Berger MM et al. (7 authors)
- DOI
- 10.1093/ajcn/80.2.410
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at the intervention named in the title.
The objective was to study trace element balances during continuous renal replacement therapy (CRRT) in intensive care patients.
Why It Was Studied
Acute renal failure is a serious complication in critically ill patients and frequently requires renal replacement therapy, which alters trace element and vitamin metabolism.
Who Took Part
PubMed indexes the participants as middle-aged adults and older adults, both men and women.
In a prospective randomized crossover trial, patients with acute renal failure received CRRT with either sodium bicarbonate (Bic) or sodium lactate (Lac) as a buffering agent over 2 consecutive 24-h periods.
Copper, selenium, zinc, and thiamine were measured with highly sensitive analytic methods in plasma, replacement solutions, and effluent during 8-h periods.
How the Study Was Run
The researchers set it up as a randomized and crossover study.
Random assignment meant chance, not the researchers, decided who got the intervention named in the title and who got the comparison, which limits bias.
In the crossover set-up each of the participants took both the intervention named in the title and the comparison in turn, acting as their own control.
Balances were calculated as the difference between fluids administered and effluent losses and were compared with the recommended intakes (RI) from parenteral nutrition.
What Was Measured
PubMed files the paper under topics including Acute Kidney Injury, Copper, Critical Care, Hemodiafiltration, Selenium, Thiamine and Zinc.
What This Means in Plain Language
The paper is a randomized and crossover study.
Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2004 (The American journal of clinical nutrition), a journal based in United States.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.