Baseline and CRH-stimulated ACTH and cortisol levels after administration of the peroxisome proliferator-activated receptor-gamma ligand, rosiglitazone, in Cushing's disease

What Was Tested

This randomized controlled trial paper looks at ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).

The 4 tests were performed in all subjects in randomized order on different days.

Who Took Part

The abstract describes 8 women taking part.

The age groups tagged for this paper are teenagers, adults, middle-aged adults and older adults, both men and women.

Ten patients (8 women and 2 men, aged 18-65 yr) with Cushing's disease were enrolled in the study: 6 of them had previously undergone unsuccessful surgery and 4 were untreated.

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got ACTH (Corticotropin) and who got the comparison, which limits bias.

What Was Measured

The 4 tests were performed in all subjects in randomized order on different days.

The subject headings attached to it are Adrenocorticotropic Hormone, Corticotropin-Releasing Hormone, Hydrocortisone, Hypoglycemic Agents, Ligands, PPAR gamma and Pituitary ACTH Hypersecretion.

What This Means in Plain Language

The paper is a randomized study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone) in 8 women.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 1 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2004 (Journal of endocrinological investigation), a journal based in Italy.

More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.