Comparison of sequential versus simultaneous methods of adrenal venous sampling.

What Was Tested

Researchers studied Adrenocorticotropic Hormone in this clinical trial publication.

To compare two methods of adrenal venous sampling (AVS) in preoperative localization of adrenal lesions in primary hyperaldosteronism.

Who Took Part

According to the abstract, 13 men were involved.

The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.

Twenty-one patients (13 men, eight women) underwent selective adrenal venous sampling between July 2001 and May 2003.

One of the 21 patients underwent repeat AVS, for a total of 22 procedures.

How the Study Was Run

In half the procedures (n = 11), simultaneous bilateral adrenal venous catheterization and sampling was performed before and after intraprocedural adrenocorticotropic hormone (ACTH) administration; in the remaining half (n = 11), sequential catheterization of the left and right adrenal veins was performed during continuous ACTH infusion 1 hour before and throughout AVS.

Chart review provided procedural data, including sampling intervals and aldosterone/cortisol ratios.

Patient records provided clinical data, including blood pressure, serum aldosterone levels, and computed tomography and magnetic resonance imaging findings.

Surgical pathology reports confirmed unilateral disease but were not applicable to bilateral disease.

What Was Measured

PubMed files the paper under topics including Adrenal Glands, Adrenalectomy, Adrenocorticotropic Hormone, Aldosterone, Catheterization, Peripheral, Hydrocortisone and Hyperaldosteronism.

What This Means in Plain Language

This is a clinical trial of Adrenocorticotropic Hormone in 13 men.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 10 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2004 (Journal of vascular and interventional radiology : JVIR), a journal based in United States.

More context: the related ACTH (Corticotropin) library page, all human trials.