Effect of urinary versus recombinant follicle-stimulating hormone on platelet function and other hemostatic variables in controlled ovarian hyperstimulation.

Plain-language guide to PMID 15589861 (2004): randomized controlled trial of Follicle Stimulating Hormone and Estradiol in 24 women.

Key Facts

PMID: 15589861
Journal: Fertility and sterility
Year: 2004
Study type: Randomized Controlled Trial
Authors: Bar J et al. (6 authors)
DOI: 10.1016/j.fertnstert.2004.04.066

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Follicle Stimulating Hormone and Estradiol.

To determine the effect of urinary versus recombinant FSH on platelet function and hemostatic variables in women undergoing controlled ovarian hyperstimulation cycles.

Who Took Part

The study group was 24 women.

By PubMed's age tags, the people studied were adults, women only.

Ten healthy women (in vitro study), and 24 women undergoing routine controlled ovarian hyperstimulation cycles (in vivo study), randomly assigned to receive either urinary (u-FSH) or recombinant gonadotropin (r-FSH).

In vivo study: Changes in platelet function and coagulation parameters after treatment with u-FSH or r-FSH during controlled ovarian hyperstimulation cycles.

How the Study Was Run

The researchers set it up as a randomized study.

The women were allocated by chance, so the Follicle Stimulating Hormone group and the comparison group should start out alike.

Major university-based infertility and in vitro fertilization unit and hemostasis laboratory.

In vitro study: effect of preincubation of plasma with u-FSH or r-FSH, in the presence or absence of estradiol, on platelet function and coagulation parameters.

What Was Measured

Topics PubMed links to this paper include Activated Protein C Resistance, Adenosine Triphosphate, Blood Platelets, Estradiol, Follicle Stimulating Hormone, Follicle Stimulating Hormone, Human and Hemostasis.

What This Means in Plain Language

The paper is a randomized study of Follicle Stimulating Hormone and Estradiol in 24 women.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2004 (Fertility and sterility), a journal based in United States.

More context: all human trials.

All human trials and studies

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.