The effect of statins on angiotensin II-induced hemodynamic changes in young, mildly hypercholesterolemic men

What Was Tested

This randomized controlled trial paper looks at Angiotensin II.

Angiotensin II type 1 (AT(1)) receptors are well known to mediate angiotensin II (Ang II)-induced pro-atherosclerotic effects.

The researchers analyzed to what extent statins and AT(1) receptor antagonists diminish the vasoconstrictive response to Ang II infusion in hypercholesterolemic patients.

Who Took Part

The study group was 24 patients.

The age groups tagged for this paper are teenagers, adults and middle-aged adults, men only.

Hemodynamic changes were also compared with those in 24 normocholesterolemic subjects without any therapy.

How the Study Was Run

In design terms this was a randomized and crossover study.

The patients were allocated by chance, so the Angiotensin II group and the comparison group should start out alike.

In the crossover set-up each of the patients took both Angiotensin II and the comparison in turn, acting as their own control.

What Was Measured

The subject headings attached to it are Angiotensin II, Angiotensin II Type 1 Receptor Blockers, Benzimidazoles, Biomarkers, Biphenyl Compounds, Blood Pressure and Cholesterol, HDL.

What This Means in Plain Language

The paper is a randomized and crossover study of Angiotensin II in 24 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2004 (American journal of hypertension), a journal based in United States.

More context: the Angiotensin II compound page, all human trials.