[Clinical study of subcutaneous administration of gonadotropin-releasing hormone agonist every six weeks in girls with idiopathic central precocious puberty].

What Was Tested

The paper reports a study of Gonadotropin-Releasing Hormone, published as a randomized controlled trial.

The aim of this study was to assess the feasibility of subcutaneous administration of Triptorelin with a prolonged interval (six weeks) for the suppression of pituitary-gonadal axis and clinical signs in girls with idiopathic central precocious puberty (ICPP).

Who Took Part

The abstract describes 26 patients taking part.

PubMed tags the participants as women only.

Forty-six girls with ICPP were enrolled in this trial and were divided into two groups at random, with 26 patients in group A and 20 in group B.

During the period of treatment, the clinical parameters including height, weight, pubertal stage, bone age, uterine volume and ovarian size were documented.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Gonadotropin-Releasing Hormone study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Both forms were given for more than 12 months consecutively.

The serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH) and estradiol (E(2)) were monitored using immunoenzymometric assay.

What Was Measured

Topics PubMed links to this paper include Body Height, Breast, Feasibility Studies, Gonadotropin-Releasing Hormone, Puberty, Precocious, Triptorelin Pamoate and Uterus.

What This Means in Plain Language

The paper is a randomized study of Gonadotropin-Releasing Hormone in 26 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 17 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2004 (Zhonghua er ke za zhi = Chinese journal of pediatrics), a journal based in China.

More context: all human trials.