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Effect of intermittent administration of [amount hidden] intranasal salmon calcitonin and low doses of 1alpha(OH) vitamin D3 on bone mineral density of the lumbar spine and hip region and biochemical bone markers in women with postmenopausal osteoporosis: a pilot study
Plain-language guide to PMID 15647969 (2005): pilot randomized controlled trial study of Calcitonin in 102 women, osteoporosis and bone density.
Key Facts
- PMID
- 15647969
- Journal
- Clinical rheumatology
- Year
- 2005
- Study type
- Randomized Controlled Trial
- Authors
- Kaskani E et al. (12 authors)
- DOI
- 10.1007/s10067-004-1004-6
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Calcitonin in the context of osteoporosis and bone density, published as a randomized controlled trial.
Baseline characteristics of participants, including age, body mass index, lumbar and hip BMD, and biochemical markers were similar between the two groups.
A total of 91 patients completed the study (50 in the salmon calcitonin nasal spray group and 41 in the other group).
Who Took Part
The study group was 102 women.
By PubMed's age tags, the people studied were middle-aged adults and older adults, women only.
BMD of the lumbar spine and hip plus biochemical markers reflecting calcium (Ca) metabolism and bone turnover [serum Ca, serum phosphorus, intact parathormone (iPTH), total and bone-specific alkaline phosphatase, osteocalcin levels, 24-h urinary Ca, morning fasting urinary Ca/creatinine, and Pyrilinks-D/creatinine ratio] were measured at the beginning of the study before treatment and after 6 and 12 months of treatment.
How the Study Was Run
The researchers set it up as a randomized and pilot study.
Because people in this Calcitonin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
It is described as a pilot, a small early test of whether a larger Calcitonin study would be practical.
What Was Measured
The subject headings attached to it are Absorptiometry, Photon, Adjuvants, Immunologic, Alkaline Phosphatase, Analgesics, Biomarkers, Bone Density and Calcitonin.
What This Means in Plain Language
The paper is a randomized and pilot study of Calcitonin in 102 women in people with osteoporosis and bone density.
The publication is from 2005 (Clinical rheumatology), a journal based in Germany.
More context: the Calcitonin compound page, Osteoporosis and bone density research.
Our Notes on the Compound
Calcitonin: A 32-amino-acid hormone that lowers blood calcium; salmon calcitonin (Miacalcin) has been used for Paget disease and osteoporosis.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.