Intraindividual blood pressure responses to angiotensin-converting enzyme inhibition and angiotensin receptor blockade.

What Was Tested

Researchers studied Angiotensin-Converting Enzyme Inhibitors and Lisinopril in the context of low blood pressure and orthostatic hypotension in this randomized controlled trial publication.

This study aims to test the hypothesis that in some hypertensive subjects the blood pressure (BP) response to angiotensin-converting enzyme inhibition differs from that to angiotensin receptor blockade (ARB); a responder to angiotensin-converting enzyme inhibition may not respond to ARB or the opposite.

Why It Was Studied

Subjects were classified as "responders" and "nonresponders" using an arbitrary threshold of ambulatory BP response (> or =10 mm Hg systolic or > or =5 diastolic) or the median response achieved by each drug.

Who Took Part

PubMed indexes the participants as middle-aged adults, both men and women.

How the Study Was Run

The design is described as randomized, open-label and crossover.

The participants were allocated by chance, so the Angiotensin-Converting Enzyme Inhibitors group and the comparison group should start out alike.

Everyone knew when Angiotensin-Converting Enzyme Inhibitors was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.

In the crossover set-up each of the participants took both Angiotensin-Converting Enzyme Inhibitors and the comparison in turn, acting as their own control.

What Was Measured

Topics PubMed links to this paper include Angiotensin II Type 1 Receptor Blockers, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Benzimidazoles, Benzoates, Blood Pressure and Blood Pressure Monitoring, Ambulatory.

What This Means in Plain Language

The paper is a randomized, open-label and crossover study of Angiotensin-Converting Enzyme Inhibitors and Lisinopril in people with low blood pressure and orthostatic hypotension.

The publication is from 2005 (Journal of clinical hypertension (Greenwich, Conn.)), a journal based in United States.

More context: Low blood pressure and orthostatic hypotension research.