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The CGRP-antagonist, BIBN4096BS does not affect cerebral or systemic haemodynamics in healthy volunteers
Plain-language guide to PMID 15658951 (2005): double-blind randomized controlled trial study of CGRP (Calcitonin Gene-Related Peptide).
Key Facts
- PMID
- 15658951
- Journal
- Cephalalgia : an international journal of headache
- Year
- 2005
- Study type
- Randomized Controlled Trial
- Authors
- Petersen KA et al. (7 authors)
- DOI
- 10.1111/j.1468-2982.2004.00830.x
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of CGRP (Calcitonin Gene-Related Peptide), published as a randomized controlled trial.
Blocking the receptor of a strong vasodilator involves a theoretical risk of causing cerebral vasoconstriction, a probability not previously investigated with BIBN4096BS.
Seven healthy volunteers completed this double-blinded placebo-controlled crossover study.
Who Took Part
PubMed indexes the participants as adults, both men and women.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and crossover.
Random assignment meant chance, not the researchers, decided who got CGRP (Calcitonin Gene-Related Peptide) and who got the comparison, which limits bias.
Blinding on both sides kept the participants and researchers unaware of who received CGRP (Calcitonin Gene-Related Peptide).
A placebo (an inactive look-alike) gave the CGRP (Calcitonin Gene-Related Peptide) group a baseline to be compared against.
Each person switched between CGRP (Calcitonin Gene-Related Peptide) and the comparison at some point, usually with a gap in between.
Transcranial Doppler was used to measure the middle cerebral artery blood flow velocity (V(MCA)); global and regional cerebral blood flow (rCBF(MCA)) was measured by 133-Xenon inhalation SPECT.
The diameter of the temporal and radial artery was measured by high-resolution ultrasound.
What Was Measured
The subject headings attached to it are Blood Pressure, Brain, Calcitonin Gene-Related Peptide, Cerebrovascular Circulation, Heart Rate, Piperazines and Quinazolines.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of CGRP (Calcitonin Gene-Related Peptide).
The publication is from 2005 (Cephalalgia : an international journal of headache), a journal based in England.
More context: the CGRP (Calcitonin Gene-Related Peptide) compound page, all human trials.
Our Notes on the Compound
CGRP (Calcitonin Gene-Related Peptide): A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.