Basal and stimulation day 5 anti-Mullerian hormone serum concentrations as predictors of ovarian response and pregnancy in assisted reproductive technology cycles stimulated with gonadotropin-releasing hormone agonist--gonadotropin treatment.

What Was Tested

Researchers studied Gonadotropin-Releasing Hormone in this randomized controlled trial publication.

The present study was undertaken to investigate the usefulness of baseline cycle day 3 AMH levels and AMH serum concentrations obtained on the fifth day of gonadotropin therapy in predicting ovarian response and pregnancy in women undergoing ovarian stimulation with FSH under pituitary desensitization for assisted reproduction.

Why It Was Studied

Anti-Müllerian hormone (AMH) has been recently proposed as a marker for ovarian ageing and poor ovarian response to controlled ovarian hyperstimulation in assisted reproduction cycles.

Who Took Part

The abstract describes 80 women taking part.

By PubMed's age tags, the people studied were adults, women only.

As a control group, 60 women were randomly selected from their assisted reproduction programme matching by race, age, body mass index, basal FSH and indication for IVF/ICSI to those in the cancelled group.

For each cancelled patient, three IVF/ICSI women who met the matching criteria were included.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got Gonadotropin-Releasing Hormone and who got the comparison, which limits bias.

Twenty consecutive cycles which were cancelled because of a poor follicular response were initially selected.

What Was Measured

PubMed files the paper under topics including Anti-Mullerian Hormone, Biomarkers, Estradiol, Fertilization in Vitro, Follicle Stimulating Hormone, Glycoproteins and Gonadotropin-Releasing Hormone.

What This Means in Plain Language

The paper is a randomized study of Gonadotropin-Releasing Hormone in 80 women.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2005 (Human reproduction (Oxford, England)), a journal based in England.

More context: all human trials.