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The treatment of osteoporosis in patients with rheumatoid arthritis receiving glucocorticoids: a comparison of alendronate and intranasal salmon calcitonin
Plain-language guide to PMID 15688191 (2005): randomized controlled trial study of Calcitonin, rheumatoid arthritis.
Key Facts
- PMID
- 15688191
- Journal
- Rheumatology international
- Year
- 2005
- Study type
- Randomized Controlled Trial
- Authors
- Tascioglu F et al. (5 authors)
- DOI
- 10.1007/s00296-004-0496-3
What This Study Did, in Plain Language
What Was Tested
Researchers studied Calcitonin in the context of rheumatoid arthritis in this randomized controlled trial publication.
Who Took Part
PubMed indexes the participants as middle-aged adults, women only.
Bone metabolism measurements included urinary deoxypyridinoline (DPD), serum bone alkaline phosphatase (BAP), and serum osteocalcin (OC).
How the Study Was Run
In design terms this was a randomized study.
Random assignment meant chance, not the researchers, decided who got Calcitonin and who got the comparison, which limits bias.
Bone mineral density (BMD) of the lumbar spine, femoral neck, and trochanter was measured annually using dual-energy X-ray absorptiometry.
What Was Measured
The subject headings attached to it are Absorptiometry, Photon, Administration, Inhalation, Alendronate, Alkaline Phosphatase, Amino Acids, Arthritis, Rheumatoid and Bone Density.
What This Means in Plain Language
The paper is a randomized study of Calcitonin in people with rheumatoid arthritis.
Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2005 (Rheumatology international), a journal based in Germany.
More context: the Calcitonin compound page, Rheumatoid arthritis research.
Our Notes on the Compound
Calcitonin: A 32-amino-acid hormone that lowers blood calcium; salmon calcitonin (Miacalcin) has been used for Paget disease and osteoporosis.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.