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Ghrelin response to carbohydrate-enriched breakfast is related to insulin
Plain-language guide to PMID 15699223 (2005): double-blind randomized controlled trial study of Ghrelin.
Key Facts
- PMID
- 15699223
- Journal
- The American journal of clinical nutrition
- Year
- 2005
- Study type
- Randomized Controlled Trial
- Authors
- Blom WA et al. (6 authors)
- DOI
- 10.1093/ajcn.81.2.367
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Ghrelin, published as a randomized controlled trial.
The researchers examined the effects of both amount and type of carbohydrate on ghrelin concentrations and all correlations among the variables ghrelin, glucose, insulin, leptin, and all 4 subjective measures of appetite.
Why It Was Studied
Ghrelin plays an important role in the regulation of food intake.
Little is known about how ghrelin concentrations are modified by dietary factors.
Who Took Part
PubMed indexes the participants as adults and middle-aged adults, men only.
Subjective measures of appetite and concentrations of ghrelin, glucose, insulin, and leptin were frequently assessed for 4 h after liquid breakfast meals differing in energy content and carbohydrate structure-ie, water, low-calorie (LC) meal, high-calorie simple carbohydrate (HC-SC) meal, and high-calorie complex carbohydrate (HC-CC) meal.
How the Study Was Run
The researchers set it up as a randomized, double-blind and crossover study.
Because people in this Ghrelin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the participants and researchers unaware of who received Ghrelin.
Each person switched between Ghrelin and the comparison at some point, usually with a gap in between.
What Was Measured
The subject headings attached to it are Analysis of Variance, Appetite, Area Under Curve, Blood Glucose, Carbohydrates, Dietary Carbohydrates and Dietary Fats.
What This Means in Plain Language
The paper is a randomized, double-blind and crossover study of Ghrelin.
Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2005 (The American journal of clinical nutrition), a journal based in United States.
More context: the Ghrelin compound page, all human trials.
Our Notes on the Compound
Ghrelin: A 28-amino-acid stomach hormone that signals hunger and triggers growth hormone release; studied in human trials as an infusion.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.