Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men.

What Was Tested

The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a randomized controlled trial.

The researchers investigated the impact of growth hormone (GH) alone, testosterone (T) alone, and combined GH and T on whole body protein metabolism.

Twelve hypopituitary men participated in two studies.

Who Took Part

PubMed indexes the participants as adults, middle-aged adults and older adults, men only.

How the Study Was Run

In design terms this was a randomized and crossover study.

The participants were allocated by chance, so the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group and the comparison group should start out alike.

Each person switched between Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and the comparison at some point, usually with a gap in between.

IGF-I, resting energy expenditure (REE), and fat oxidation (F(ox)) and rates of whole body leucine appearance (R(a)), oxidation (L(ox)), and nonoxidative leucine disposal (NOLD) were measured.

What Was Measured

The researchers investigated the impact of growth hormone (GH) alone, testosterone (T) alone, and combined GH and T on whole body protein metabolism.

In study 2, T alone did not alter IGF-I levels.

Topics PubMed links to this paper include Adenoma, Anabolic Agents, Basal Metabolism, Body Composition, Drug Synergism, Energy Metabolism and Growth Hormone.

What This Means in Plain Language

The paper is a randomized and crossover study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The publication is from 2005 (American journal of physiology. Endocrinology and metabolism), a journal based in United States.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.