Time-course of morphologic changes and peptide YY adaptation in ileal mucosa after loop ileostomy in humans

What Was Tested

This controlled clinical trial paper looks at Peptide YY.

The secretion mechanism of peptide YY involves systemic factors, such as humoral and neural stimuli, and local factors, such as intestinal peristalsis and intraluminal nutrients.

This study was designed to survey the impact of local stimuli on the secretion of peptide YY under circumstances in which systemic stimuli are identical.

Who Took Part

According to the abstract, 14 patients were involved.

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

Ileostomies were repaired within three months in a short-term group (14 patients) and after six months in a long-term group (14 patients).

In a control group of patients undergoing right hemicolectomy (21 cases), the normal distribution of peptide YY was measured in the mucosa throughout the distal ileum.

How the Study Was Run

A time span of three months appears in the methods.

Mucosal peptide YY concentrations and cytomorphologic change, such as villus height, crypt depth, mucosal thickness, and villus index, were compared between proximal functioning ileum and a distal nonfunctioning ileal loop during ileostomy repair.

What Was Measured

PubMed files the paper under topics including Adaptation, Physiological, Ileostomy, Ileum, Intestinal Absorption, Intestinal Mucosa and Peptide YY.

What This Means in Plain Language

This is a controlled clinical trial of Peptide YY in 14 patients over three months.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 9 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2005 (Diseases of the colon and rectum), a journal based in United States.

More context: the Peptide YY compound page, all human trials.