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Luteal phase support with hCG does not improve fecundity rate in human menopausal gonadotropin-stimulated cycles
Plain-language guide to PMID 1579327 (1992): crossover randomized controlled trial study of hCG (human chorionic gonadotropin) and HMG (Human Menopausal Gonadotropin).
Key Facts
- PMID
- 1579327
- Journal
- Obstetrics and gynecology
- Year
- 1992
- Study type
- Randomized Controlled Trial
- Authors
- Keenan JA et al. (2 authors)
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of hCG (human chorionic gonadotropin) and HMG (Human Menopausal Gonadotropin), published as a randomized controlled trial.
Therefore, a randomized cross-over study was performed to evaluate the effects of luteal phase hCG administration on pregnancy rates during ovulation induction with hMG.
Why It Was Studied
The luteal phase of cycles stimulated with human menopausal gonadotropins (hMG) may be characterized by aberrant hormone levels, altered endometrial development, and shortened length.
Sixty-seven infertile women were randomly assigned to either group A (N = 33) or group B (N = 34).
Who Took Part
The age groups tagged for this paper are adults, women only.
Patients in group A received supplemental hCG in odd-numbered cycles, whereas group B was given luteal support in even-numbered cycles.
How the Study Was Run
The design is described as randomized and crossover.
The participants were allocated by chance, so the hCG (human chorionic gonadotropin) group and the comparison group should start out alike.
Each person switched between hCG (human chorionic gonadotropin) and the comparison at some point, usually with a gap in between.
What Was Measured
The luteal phase of cycles stimulated with human menopausal gonadotropins (hMG) may be characterized by aberrant hormone levels, altered endometrial development, and shortened length.
The subject headings attached to it are Chorionic Gonadotropin, Fertilization in Vitro, Infertility, Female, Luteal Phase, Menotropins, Ovulation Induction and Progesterone.
What This Means in Plain Language
The paper is a randomized and crossover study of hCG (human chorionic gonadotropin) and HMG (Human Menopausal Gonadotropin).
The publication is from 1992 (Obstetrics and gynecology), a journal based in United States.
More context: the hCG (human chorionic gonadotropin) compound page and the HMG (Human Menopausal Gonadotropin) compound page, all human trials.
Our Notes on the Compounds
hCG (human chorionic gonadotropin): An LH analog that drives Leydig-cell testosterone production.
HMG (Human Menopausal Gonadotropin): Menotropins: a glycoprotein preparation that supplies follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.