The pharmacokinetics of 400 microg of oral desmopressin in elderly patients with nocturia, and the correlation between the absorption of desmopressin and clinical effect

What Was Tested

This randomized controlled trial paper looks at Vasopressin and Desmopressin.

Who Took Part

The study group was 32 patients.

The age groups tagged for this paper are older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.

Because people in this Vasopressin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the patients nor the staff measuring them knew who was on Vasopressin, so expectations could not easily colour the readings.

Some patients received a placebo instead of Vasopressin, giving a reference point.

In the crossover set-up each of the patients took both Vasopressin and the comparison in turn, acting as their own control.

What Was Measured

The subject headings attached to it are Absorption, Area Under Curve, Deamino Arginine Vasopressin, Renal Agents and Urination Disorders.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vasopressin and Desmopressin in 32 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2005 (BJU international), a journal based in England.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.