Effect of moderate incremental exercise, performed in fed and fasted state on cardio-respiratory variables and leptin and ghrelin concentrations in young healthy men

What Was Tested

Researchers studied Ghrelin in this clinical trial publication.

This study was designed to determine the effect of overnight fasting on cardio- respiratory responses during moderate incremental exercise.

The researchers have hypothesised that fasting / exercise induced changes in plasma leptin / ghrelin concentrations may influence cardiovascular response.

Why It Was Studied

Although hormonal responses to exercise performed in fed state are well documented, far less in known about the effect of a single exercise bout, performed after overnight fasting, on cardio-respiratory responses and hormones secretion.

It has been reported that recently discovered hormones as leptin and ghrelin may affect cardiovascular responses at rest.

Who Took Part

PubMed indexes the participants as adults, men only.

Eight healthy non-smoking men (means +/- SE.: age 23.0 +/- 0.5 years; body mass 71.9 +/- 1.5 kg; height 179.1 +/- 0.8 cm; BMI 22.42 +/- 0.49 kg x m(-2) with VO2max of 3.71 +/- 0.10 l x min(-1)) volunteered for this study.

How the Study Was Run

The researchers set it up as a randomized study.

The participants were allocated by chance, so the Ghrelin group and the comparison group should start out alike.

Tests were performed in a random order: once in the feed state--cycling until exhaustion and second, about one week later, after overnight fasting--cycling until reaching 150 W.

What Was Measured

Topics PubMed links to this paper include Exercise, Fasting, Gastrins, Ghrelin, Heart Rate, Insulin and Interleukin-6.

What This Means in Plain Language

The paper is a randomized study of Ghrelin.

Its findings take up roughly 12 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2005 (Journal of physiology and pharmacology : an official journal of the Polish Physiological Society), a journal based in Poland.

More context: the Ghrelin compound page, all human trials.