[Effect of glutathione pretreatment on lung ischemia-reperfusion injury during cardiopulmonary bypass]

What Was Tested

Researchers studied Glutathione in this randomized controlled trial publication.

To observe the clinical effect of glutathione (GSH) pretreatment on lung ischemia-reperfusion injury during cardiopulmonary bypass (CPB) and determine the mechanism.

Who Took Part

By PubMed's age tags, the people studied were adults, both men and women.

Sixteen patients ready to replace heart valve(s) were randomly divided into the control and the treatment group.

GSH diluted with normal saline solution was injected to the patients in the treatment group 36 h before the operation, while normal saline solution was injected to the patients in the control group.

How the Study Was Run

The design is described as randomized.

Because people in this Glutathione study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Malondiadehyde (MDA), Factor V III (FV III) and free hemoglobin (FHb) were detected in the left and right heart chamber at pre-CPB 5, 10, and 15 minutes after the heart resuscitation.

The differences between the left and right were recorded.

Arterial blood from the radius was analyzed for PO2/FiO2 at pre-CPB, 10 min, 1 h and 6 h after the heart resuscitation.

What Was Measured

The subject headings attached to it are Cardiopulmonary Bypass, Cerebrovascular Circulation, Glutathione, Heart Valve Prosthesis Implantation, Ischemic Preconditioning, Lung and Reperfusion Injury.

What This Means in Plain Language

The paper is a randomized study of Glutathione.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2003 (Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University), a journal based in China.

More context: the Glutathione compound page, all human trials.