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Testosterone suppression of CRH-stimulated cortisol in men.
Plain-language guide to PMID 15841103 (2005): double-blind randomized controlled trial of Testosterone and Leuprolide in 10 men.
Key Facts
- PMID
- 15841103
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- Year
- 2005
- Study type
- Randomized Controlled Trial
- Authors
- Rubinow DR et al. (8 authors)
- DOI
- 10.1038/sj.npp.1300742
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Testosterone and Leuprolide, published as a randomized controlled trial.
Despite observations of age-dependent sexual dimorphisms in hypothalamic-pituitary-adrenal (HPA) axis activity, the role of androgens in the regulation of HPA axis activity in men has not been examined.
The researchers assessed this role by performing CRH stimulation tests in 10 men (ages 18-45 years) during gonadal suppression with leuprolide acetate and during testosterone addition to leuprolide.
Who Took Part
The study group was 10 men.
The age groups tagged for this paper are teenagers, adults and middle-aged adults, men only.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Testosterone and who got the comparison, which limits bias.
Blinding on both sides kept the men and researchers unaware of who received Testosterone.
The comparison arm used a placebo, so changes seen with Testosterone could be set against what happens without it.
What Was Measured
The researchers assessed this role by performing CRH stimulation tests in 10 men (ages 18-45 years) during gonadal suppression with leuprolide acetate and during testosterone addition to leuprolide.
PubMed files the paper under topics including Adrenocorticotropic Hormone, Area Under Curve, Corticotropin-Releasing Hormone, Drug Interactions, Hydrocortisone, Leuprolide and Radioimmunoassay.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Testosterone and Leuprolide in 10 men.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2005 (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology), a journal based in England.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.