Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty.

What Was Tested

This randomized controlled trial looks at Calcium.

Few studies of the VDR polymorphisms have looked at calcium metabolism or long-term effects.

The researchers measured bone mineralization and calcium metabolic parameters longitudinally in a group of 99 adolescents.

Who Took Part

According to the abstract, 99 adolescents were involved.

By PubMed's age tags, the people studied were children, both men and women.

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

Because people in this Calcium study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

A placebo (an inactive look-alike) gave the Calcium group a baseline to be compared against.

Adolescents (n = 99) received comprehensive stable isotope studies of calcium absorption, bone calcium kinetics, and bone mineralization.

Studies were repeated 12 months later.

Polymorphisms of putative genetic markers were determined and related to bone mineralization and calcium metabolic finding.

Results were analyzed by ANOVA in which changes over time were determined using the initial value as a covariate.

What Was Measured

The researchers measured bone mineralization and calcium metabolic parameters longitudinally in a group of 99 adolescents.

Topics PubMed links to this paper include Analysis of Variance, Bone Density, Bone and Bones, Calcium, Diet, Fructans and Genotype.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Calcium in 99 adolescents.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2005 (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research), a journal based in England.

More context: all human trials.