Reduced oral itraconazole bioavailability by antacid suspension.

What Was Tested

This randomized controlled trial looks at Itraconazole.

To investigate the effects of antacid suspension on oral absorption of itraconazole.

Who Took Part

The abstract describes 12 volunteers taking part.

PubMed indexes the participants as teenagers, adults and middle-aged adults, men only.

A randomized, open-labelled, two-period, crossover study with a 1-week washout period was conducted in 12 healthy Thai male volunteers.

The participants were allocated in either treatment A or B in the first period.

How the Study Was Run

In design terms this was a randomized, open-label and crossover study.

The volunteers were allocated by chance, so the Itraconazole group and the comparison group should start out alike.

Being open-label, the Itraconazole study did not mask who received what.

Each person switched between Itraconazole and the comparison at some point, usually with a gap in between.

Serial serum samples were collected over the period of 24 h and subsequently analysed by using a validated high-pressure liquid chromatographic method with ultraviolet detection.

What Was Measured

The subject headings attached to it are Aluminum Hydroxide, Antacids, Antifungal Agents, Area Under Curve, Biological Availability, Drug Antagonism and Drug Combinations.

What This Means in Plain Language

The paper is a randomized, open-label and crossover study of Itraconazole in 12 volunteers.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2005 (Journal of clinical pharmacy and therapeutics), a journal based in England.

More context: all human trials.