Effect of exercise on transdermal nicotine release in healthy habitual smokers

What Was Tested

This randomized controlled trial paper looks at Therapeutic nicotine (patch, non-peptide).

Transdermal nicotine patches have become a frequently prescribed tool in smoking cessation programs during the past years.

However, there is circumstantial evidence that transdermal nicotine release substantially varies with physical activity producing toxic plasma concentrations that may account for severe adverse events.

Who Took Part

By PubMed's age tags, the people studied were adults, men only.

The researchers, therefore, compared nicotine release from two different transdermal nicotine systems (TDNS) at rest and during strenuous physical activity in a two-period crossover study in healthy smokers (n = 10).

How the Study Was Run

In design terms this was a randomized and crossover study.

Because people in this Therapeutic nicotine (patch, non-peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In the crossover set-up each of the participants took both Therapeutic nicotine (patch, non-peptide) and the comparison in turn, acting as their own control.

Patches were applied eight hours before starting standardized physical activity, and nicotine concentrations were measured in plasma and topically in the tissue layers underneath the application site by microdialysis.

What Was Measured

PubMed files the paper under topics including Administration, Cutaneous, Exercise, Nicotine, Regional Blood Flow, Skin and Smoking.

What This Means in Plain Language

The paper is a randomized and crossover study of Therapeutic nicotine (patch, non-peptide).

Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2005 (International journal of clinical pharmacology and therapeutics), a journal based in Germany.

More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.