Comparison of three multiple injection regimens for Type 1 diabetes: morning plus dinner or bedtime administration of insulin detemir vs. morning plus bedtime NPH insulin

What Was Tested

The paper reports a study of Insulin Detemir and NPH Insulin (isophane), published as a randomized controlled trial.

Who Took Part

The study group was 400 people.

PubMed indexes the participants as teenagers and adults, both men and women.

How the Study Was Run

In design terms this was a randomized and parallel-group study.

Random assignment meant chance, not the researchers, decided who got Insulin Detemir and who got the comparison, which limits bias.

The Insulin Detemir group and the comparison group ran side by side rather than switching.

This multinational, 16-week, open, parallel group trial included 400 people with Type 1 diabetes mellitus (DM) randomized to IDet either morning and before dinner (IDetmorn+din) or morning and bedtime (IDetmorn+bed), or to NPH morning and bedtime (NPHmorn+bed), all in combination with mealtime insulin aspart (IAsp).

What Was Measured

Topics PubMed links to this paper include Blood Glucose, Diabetes Mellitus, Type 1, Glycated Hemoglobin, Hypoglycemia, Hypoglycemic Agents, Insulin and Insulin Detemir.

What This Means in Plain Language

The paper is a randomized and parallel-group study of Insulin Detemir and NPH Insulin (isophane) in 400 people.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2005 (Diabetic medicine : a journal of the British Diabetic Association), a journal based in England.

More context: the Insulin Detemir compound page and the NPH Insulin (isophane) compound page, all human trials.