A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control

What Was Tested

The paper reports a study of Pancreatic Polypeptide, published as a randomized controlled trial.

The objective of this study was to use synthetic human PP to study gastric emptying rates of a solid meal and postprandial hormone secretion and glucose disposal as well as the gastric emptying rate of water.

Why It Was Studied

Previous studies using pancreatic polypeptide (PP) infusions in humans have failed to show an effect on gastric emptying, glucose metabolism, and insulin secretion.

This might be due to the use of nonhuman sequences of the peptide.

Who Took Part

The age groups tagged for this paper are adults, both men and women.

How the Study Was Run

The design is described as randomized, single-blind and crossover.

The participants were allocated by chance, so the Pancreatic Polypeptide group and the comparison group should start out alike.

Only one side, usually the participants, was kept unaware of whether Pancreatic Polypeptide was given.

Each person switched between Pancreatic Polypeptide and the comparison at some point, usually with a gap in between.

This was a single-blind study.

The study was performed at a university hospital.

What Was Measured

PubMed files the paper under topics including Appetite, Blood Glucose, Eating, Food, Gastric Emptying, Glucagon and Hormones.

What This Means in Plain Language

The paper is a randomized, single-blind and crossover study of Pancreatic Polypeptide.

The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2005 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Pancreatic Polypeptide compound page, all human trials.