← Human Trials & Peer-Reviewed Studies
Adrenocortical response to ovine corticotropin-releasing hormone in young men: cortisol measurement in matched samples of saliva and plasma
Plain-language guide to PMID 16103684 (2005): clinical trial study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).
Key Facts
- PMID
- 16103684
- Journal
- Hormone research
- Year
- 2005
- Study type
- Clinical Trial
- Authors
- Kumar AM et al. (4 authors)
- DOI
- 10.1159/000087381
What This Study Did, in Plain Language
What Was Tested
Researchers studied ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone) in this clinical trial publication.
Salivary cortisol measurement presents a non-invasive alternate approach to evaluate HPA axis activity in different situations.
Why It Was Studied
Assessment of hypothalamic-pituitary-adrenal (HPA) axis function in stress-related health problems in humans is frequently carried out as a dynamic test by measuring the profile of increment in adrenocortical hormone (ACTH) and/or cortisol level in plasma in response to corticotropin-releasing hormone (CRH) administration.
However, obtaining multiple blood samples for this type of test is not only an invasive procedure but also problematic to use in individuals with constricted or damaged veins which collapse during the blood draw such as the injecting drug users (IDUs) and HIV-1-infected individuals.
Who Took Part
By PubMed's age tags, the people studied were adults, men only.
What Was Measured
Assessment of hypothalamic-pituitary-adrenal (HPA) axis function in stress-related health problems in humans is frequently carried out as a dynamic test by measuring the profile of increment in adrenocortical hormone (ACTH) and/or cortisol level in plasma in response to corticotropin-releasing hormone (CRH) administration.
However, obtaining multiple blood samples for this type of test is not only an invasive procedure but also problematic to use in individuals with constricted or damaged veins which collapse during the blood draw such as the injecting drug users (IDUs) and HIV-1-infected individuals.
PubMed files the paper under topics including Adrenal Cortex, Corticotropin-Releasing Hormone, Hydrocortisone, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Saliva and Sheep.
What This Means in Plain Language
This is a clinical trial of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).
Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2005 (Hormone research), a journal based in Switzerland.
More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.
Our Notes on the Compounds
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
CRH (Corticotropin-Releasing Hormone): The 41-amino-acid hypothalamic hormone that triggers ACTH release; corticorelin is used diagnostically.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.