Anti-diuretic for operational aircrew: effects of desmopressin on urine flow, cognition, and sleepiness

What Was Tested

The paper reports a study of Vasopressin and Desmopressin, published as a randomized controlled trial.

Who Took Part

The study group was 20 volunteers.

PubMed indexes the participants as adults, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and crossover study.

Because people in this Vasopressin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vasopressin study, the assignments were hidden from both participants and investigators until the end.

Some volunteers received a placebo instead of Vasopressin, giving a reference point.

Each person switched between Vasopressin and the comparison at some point, usually with a gap in between.

The study was double blind, placebo controlled, and with a randomized five-way crossover design.

What Was Measured

The subject headings attached to it are Aerospace Medicine, Aircraft, Cognition, Deamino Arginine Vasopressin, Headache, Renal Agents and Sleep.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vasopressin and Desmopressin in 20 volunteers.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2005 (Aviation, space, and environmental medicine), a journal based in United States.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.