Effect of peptide YY on pancreatico-biliary secretion in humans

What Was Tested

Researchers studied Peptide YY in this randomized controlled trial publication.

The negative feedback on pancreatico-biliary secretion induced by ileal nutrients has been well documented but the role of the distal gut peptide YY (PYY) as mediator is less well defined.

The researchers determined the effect of PYY on basal, sham feeding and feeding-stimulated pancreatico-biliary secretion in humans.

Who Took Part

PubMed indexes the participants as teenagers, adults and middle-aged adults.

Subjects were intubated with a naso-jejunal tube.

Blood samples were drawn for plasma cholecystokinin (CCK) and PYY measurements.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

Because people in this Peptide YY study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Peptide YY study, the assignments were hidden from both participants and investigators until the end.

Some participants received a placebo instead of Peptide YY, giving a reference point.

Duodenal samples were aspirated continuously while a recovery marker perfused the duodenum.

Outputs were measured in the basal state, in response to modified sham feeding (MSF) and during jejunal perfusion with a liquid meal.

What Was Measured

Topics PubMed links to this paper include Amylases, Bilirubin, Cholecystokinin, Digestion, Gallbladder, Intubation, Gastrointestinal and Pancreas.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Peptide YY.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2005 (Scandinavian journal of gastroenterology), a journal based in England.

More context: the Peptide YY compound page, all human trials.