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Immediate hedonic response to smoking lapses: relationship to smoking relapse, and effects of nicotine replacement therapy.
Plain-language guide to PMID 16283258 (2006): double-blind randomized controlled trial of Therapeutic nicotine (patch, non-peptide) in 169 subjects.
Key Facts
- PMID
- 16283258
- Journal
- Psychopharmacology
- Year
- 2006
- Study type
- Randomized Controlled Trial
- Authors
- Shiffman S et al. (3 authors)
- DOI
- 10.1007/s00213-005-0175-4
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Therapeutic nicotine (patch, non-peptide), published as a randomized controlled trial.
Smoking lapses represent an important juncture between smoking cessation and relapse.
Who Took Part
The abstract describes 169 subjects taking part.
By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.
Following their first lapse, using an electronic diary, subjects recorded the amount they smoked, and rated the pleasantness and satisfaction ("hedonic rating") and the aversiveness of smoking.
Subjects were then followed and assessed for further lapses and relapses.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Because people in this Therapeutic nicotine (patch, non-peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the subjects nor the staff measuring them knew who was on Therapeutic nicotine (patch, non-peptide), so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Therapeutic nicotine (patch, non-peptide) group a baseline to be compared against.
What Was Measured
The subject headings attached to it are Administration, Cutaneous, Affect, Attitude, Behavior Therapy, Nicotine, Reinforcement, Psychology and Risk Assessment.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Therapeutic nicotine (patch, non-peptide) in 169 subjects.
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2006 (Psychopharmacology), a journal based in Germany.
More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.
Our Notes on the Compound
Therapeutic nicotine (patch, non-peptide): Pure nicotine as a signaling tool, separated from smoking and vaping.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.