Novel biomarkers of human growth hormone action from serum proteomic profiling using protein chip mass spectrometry.

What Was Tested

The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a randomized controlled trial.

The objective of this study was to identify new serum biomarkers of GH administration using proteomic profiling.

Why It Was Studied

The detection of exogenous human GH (hGH) administration in athletes poses unique analytical problems, because its short circulating half-life provides only a brief opportunity to detect the administered hormone above endogenous levels.

Measurement of novel GH-regulated serum protein biomarkers might provide an indirect method to detect exogenous GH.

Who Took Part

The study group was 20 subjects.

PubMed indexes the participants as teenagers and adults, both men and women.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Because people in this Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the subjects and researchers unaware of who received Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

A placebo (an inactive look-alike) gave the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group a baseline to be compared against.

Sera from a previously reported, double-blind, placebo-controlled GH administration trial were analyzed by protein chip mass spectrometry.

The study was performed at clinical research centers.

What Was Measured

The detection of exogenous human GH (hGH) administration in athletes poses unique analytical problems, because its short circulating half-life provides only a brief opportunity to detect the administered hormone above endogenous levels.

Measurement of novel GH-regulated serum protein biomarkers might provide an indirect method to detect exogenous GH.

PubMed files the paper under topics including Biomarkers, Glycated Hemoglobin, Human Growth Hormone, Mass Spectrometry, Multivariate Analysis, Protein Array Analysis and Proteomics.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 20 subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2006 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.